NIH R01 · 2025
Project Summary The pathophysiology of Alzheimer’s disease (AD) is characterized by the accumulation of Amyloid (Aβ) plaques and tau neurofibrillary tangles (NFT). While the presence of both plaques (A+) and tangles (T+) are essential to the biological definition of AD as recently codified in the ATN research classification framework, tau (T) is thought to be the primary driver of downstream neurodegeneration (N) and the resulting cognitive impairment. However, there is substantial variability in the T-N relationship – manifested in higher or lower atrophy than expected for the level of tau in a given brain region, even in carefully curated research cohorts. What does this variability…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.