NIH R01 · 2024
Cell-cycle-dependent cell polarity control
PROJECT SUMMARY/ABSTRACT Polarized cells in retain their shape in every cell cycle and this is essential to their proper function. Anomalies in polarized cell shape can result in cancer, metabolic disorders, and loss of tissue integrity. Here, we will investigate a long-standing question of how cells consistently regain their polarity after each round of division. This investigation will be conducted using the fission yeast, Schizosaccharomyces pombe model system that provides many well characterized genetic tools to manipulate conserved proteins that influence cell shape following division. Cdc42 is the major regulator of polarized growth. In fission yeast, cells halt polarized Cdc42…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.