Darst Lab

Fred Hutchinson Cancer Center

Seattle · United States

NIH-funded
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Research focus

NIH R01 · 2024

Leveraging metabolomics to identify factors contributing to health disparities in Native Hawaiian individuals

1 2 Native Hawaiian individuals represent one of the most underserved and understudied populations in US 3 healthcare and medical research. However, this population is one of the fastest growing in the US and faces 4 alarming long-standing health disparities, with approximately 30% higher risk of cardiovascular disease, 100% 5 higher risk of diabetes and gout, and 400% higher risk of stroke compared to White individuals. Obesity and high 6 body mass index (BMI) are known to increase risk for these conditions, and notably, an estimated 41% of Native 7 Hawaiians are obese compared to 21% of White individuals. Native Hawaiians are characterized predominantly 8 by Polynesian, European, and East…

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