NIH R01 · 2024
Neuronal and behavioral responses to spinal cord injury
Project Summary/Abstract The toll of spinal cord injury on people and society is substantial, and particularly so when hand function is impaired and independence lost. We use well defined spinal cord injury (SCI) models in nonhuman primates and rodents to delineate the responses of major ascending and descending tracts, that reorganize post-injury and that mediate the recovery of hand function. Our past work shows that spinal injuries that remove sensory input from the opposing digits, can cause an initial deficit in hand function, from which monkeys recover over weeks and months post-lesion. This recovery occurs despite the permanent loss of most of the original sensory innervation to the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.