NIH R01 · 2024
Regulating the Detection of Reovirus Infection
Mammalian orthoreovirus (MRV) genomic RNA is detected by host cells to induce an innate immune response. Detection of MRV RNA also contributes to the induction of cell death. Because viral genomic RNA remains contained within particles throughout infection, how the RNA becomes exposed and accumulates to the level that induces a host response remains unknown. In this proposal, we will uncover how viral RNA becomes detectable by the host cell. In Aim 1 of this proposal, we will build on the data that specific endosomal uptake pathways, endosomal protease activity, and endosomal maturation are required for exposure of viral genomic RNA from incoming particles. We will identify how these…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.