Daniel-Macdougall Lab

Research focus

NIH R01 · 2025

Prebiotic diet intervention to enhance the microbiome and immunotherapy response in melanoma

PROJECT SUMMARY Treatment with immune checkpoint inhibitors (ICI) has been revolutionary in melanoma and other cancers. However, only a subset of patients will have durable responses to first-line therapy and immune-related toxicities remain a significant challenge. Given the critical, unmet need for safe, effective and broadly applicable strategies in this setting, we will conduct a prebiotic food-enriched diet (PreFED) intervention combined with standard-of-care ICI in metastatic melanoma patients. This study seeks to intervene on insights from our own work and others demonstrating that (1) gut microbiome profiles and dietary habits predict response to ICI in melanoma; (2)…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.