NIH R01 · 2025
Elevated intraocular pressure (IOP) is the only modifiable risk factor for open angle glaucoma (OAG). IOP is determined by the balance of aqueous humor production and outflow predominately through the conventional outflow tissues - the trabecular meshwork (TM) and Schlemm’s canal inner wall. TM cell dysfunction in OAG causes IOP elevation. Similar dysfunction and IOP elevation occur even in individuals without glaucoma when exposed to high enough concentrations of potent steroids for long enough periods of time. TM cells reside within a rich extracellular matrix (ECM) they synthesize and maintain. The TM ECM provides physical resistance to aqueous outflow but is also the source of cell…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.