NIH R01 · 2025
Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis
Project Summary Circadian rhythms are biological processes a period of 24 hours driven by the circadian CLOCK-BMAL1 transcription factor that regulates diurnal variations of cellular metabolism and inflammation signaling. Disruption of the circadian clock has been linked to cancer, but mechanisms of how the clock affects cancer progression are not well understood. We previously shown that oncogenic MYC could disrupt the circadian clock in cancer cells and in vivo in Drosophila and note that analysis of TCGA data indicates widespread mutations in the circadian clock circuitry genes. To address the role of the clock heterogeneity in tumor biology, we chose to study melanomas, which respond to…
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