NIH R01 · 2025
Regulation of Mitochondrial Respiration in Diabetic Kidney Disease
PROJECT SUMMARY Current treatments of diabetic kidney disease (DKD) mainly focus on managing the symptoms of diabetes and do not address the root causes of DKD. Among causal mechanisms associated with the progression of DKD, there is growing recognition of the central role of mitochondrial dysfunction. Importantly, various aspects of mitochondrial function in kidney cells are known to be impaired in experimental models and in individuals with DKD, including enhanced generation of reactive oxygen species (ROS), substantial alterations in mitochondrial dynamics and structure, and mitochondrial electron transport chain dysfunction. Dysregulated mitochondrial electron transport chain (ETC) has…
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