NIH R01 · 2024
Quinolone and acyl-homoserine lactone quorum sensing in chronic P. aeruginosa infections
Project Summary Quorum sensing (QS) is a cell-cell communication system used by many bacteria to regulate gene expression in a coordinated manner. Our work focuses on the QS system of Pseudomonas aeruginosa, a saprophyte and opportunistic pathogen of humans. P. aeruginosa uses QS to regulate dozens of genes, including several important virulence factors. P. aeruginosa QS is mediated by the transcription factors LasR and RhlR, which respond to acyl-homoserine lactone signals, and PqsR, which responds to alkylquniolone signals. Initial characterizations of QS in P. aeruginosa described a hierarchy: LasR regulates RhlR and PqsR activity. Over the past several years we, and others, have shown…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.