NIH R01 · 2025
Matrix Regenerative Nanotherapeutic Platform for Pelvic Organ Prolapse
Project Summary The goal of this research is to slow POP progression by treating early-stage pelvic organ prolapse (POP) with our novel elastogenic functionalized Nanomaterial-Drug Complexes (fNDCs). POP involves the bulging or herniation of pelvic organs and reduces quality of life for many women. POP worsens with time and surgical treatments can fail since the underlying proteolytic processes continue to degrade tissues. No existing treatment reverses this proteolytic pathophysiology. Specifically, POP pathophysiology has been linked to naturally irreversible proteolytic disruption and loss of elastic fibers. Since elastic fibers provide tissue stretch and recoil, their dysfunction can…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.