NIH R01 · 2025
Dynamics of Bone ECM Assembly and Resorption
Osteoporosis, a disease of reduced bone density that leads to bone fragility, is a major clinical problem and is primarily a disease of remodeling imbalance in which bone resorption outstrips formation. Although much progress has been made in defining the key genes and molecular pathways regulating osteoblast (OBL) and osteoclast (OCL) function and identifying targets for anti-resorptive and bone anabolic therapeutics, few studies have examined bone extracellular matrix (ECM) formation by OBL and subsequent resorption by OCL dynamically in live cells or living animals. Although the ECM was viewed as a static 3D scaffold, recent molecular imaging studies in OBL and other living systems have…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.