NIH R01 · 2025
In Vivo Acoustic Patterning for Tissue Vascularization
Microvascular insufficiency and in turn, tissue ischemia and necrosis, contribute to a variety of chronic diseases, and can be an adverse outcome of common reconstructive and plastic surgeries. The goal of this project is to advance a novel ultrasound-based technology to induce neovascularization directly in vivo, and thereby enhance local tissue perfusion. Acoustic patterning utilizes radiation forces associated with an ultrasound field to rapidly and non-invasively organize cells or microparticles volumetrically into defined geometric assemblies. We have shown that in vitro acoustic patterning of endothelial cells within collagen hydrogels leads to the formation of three-dimensional…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.