NIH R01 · 2024
Regulation of eEF-2K an Energy and Nutrient Sensor
There is a compelling need to decipher the role of the dysregulation of translation elongation in various chronic neurological conditions and many cancers. The long-term goal driving the proposed research is to help develop therapeutic strategies targeting eEF2K for treating progressive neurodegenerative diseases and malignancies. The overall objectives of this application are to (i) characterize the kinetic mechanism of eEF2K activation and regulation and (ii) elucidate the structural basis for the regulation of eEF2K by divalent cations, pH, ADP, and specific post-translational modifications. The central hypothesis is that calmodulin (CaM) binding activates eEF2K by profoundly altering…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.