NIH R01 · 2025
Combination of Antimicrobial Blue Light and Antibiotics to Combat Multidrug-Resistant Bacteria
PROJECT SUMMARY/ABSTRACT The global spread of antibiotic resistance is producing a human health crisis. The objective of this application is to investigate a novel combination therapy, by using antimicrobial blue light (aBL) with antibiotics, for synergistic antimicrobial activity and/or for the preservation/potentiation of the potency of conventional antibiotics. Our central hypothesis is that aBL+antibiotics will provide a broader action spectrum and improved antimicrobial activity through a multifunctional mode of action with both synergistic and adjuvant capabilities. To address this hypothesis, we have formulated three Specific Aims. In Aim 1, we will first investigate the potential…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.