NIH R01 · 2024
Characterization of disulfide modified diabetogenic neoepitopes
SUMMARY Polymorphisms within major histocompatibility complex class II (MHC II) genes confer significant risk for developing type 1 diabetes (T1D) in both murine models and humans. MHC class II molecules function to present processed antigens to CD4 T cells, and recent studies have identified a number of different post-translational modifications (PTM) of self-antigens in T1D including peptide fusion, deamidation, citrullination, and disulfide bond formation (S-S). Autoimmune T cell responses to neoantigens formed in peripheral tissues may explain how and why T cell responses are not subject to usual thymic education and tolerance mechanisms. Disulfide bond formation is an important PTM,…
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