NIH R01 · 2024
Metabolic reprogramming and FGF21 signaling in kidney health and polycystic kidney diseases
Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease caused by mutations in the PKD1 or PKD2 genes. Many patients often lose kidney function due to limited therapies to delay disease progression. The kidney is a highly metabolically active organ that relies on specialized tubular epithelial cells to reabsorb most of the filtered water and solutes in the body. Normal kidney tubules are highly enriched in mitochondria and preferentially use fatty acid oxidation (FAO), which generates more adenosine triphosphate (ATP) than glucose metabolism. However, one hallmark of metabolic derangement in ADPKD is decreased fatty acid oxidation (FAO) and…
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