Boodram Lab

Loyola University Chicago

INTERNAL MEDICINE/MEDICINE

Maywood · United States

NIH-funded
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NIH R01 · 2025

Computational modeling for HCV vaccine trial design and optimal vaccine-based combination interventions

PROJECT SUMMARY/ABSTRACT Despite remarkable progress with direct-acting antivirals (DAAs), hepatitis C virus (HCV) infection remains a serious global public health problem with over 1% of the world’s population and about 3 million in the United States (U.S.) infected. The U.S. Department of Health & Human Services recently renewed the Action Plan to Prevent, Care and Treat Viral Hepatitis to eliminate viral hepatitis infection as a public health threat and the WHO introduced global targets for the care and management of HCV. While the highest uptake of HCV treatment occurred in 2017 and 1.5 million people were cured, 1.6 million new infections occurred. Due to many treatment barriers, only…

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