NIH R01 · 2025
Endotoxin preconditioning as a model to uncover protective pathways in sepsis-induced renal injury
Sepsis-induced acute kidney injury remains a major clinical problem with no effective therapy established to date. Although potential therapeutic targets have been identified and tested in clinical trials, none of them has proven to be effective, underscoring the complexity of sepsis pathophysiology. Work from our laboratory identified disturbances in cell-cell communication as a major feature underlying the complex pathophysiology of sepsis-induced kidney damage. For example, pathologic signaling from S1 tubules to downstream S2/S3 tubules was a major pathway of renal injury in sepsis. Indeed, we identified the S1 proximal tubular segment as a major sensor and sink for filtered endotoxin.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.