NIH R01 · 2025
Glomerular Cell-Cell Crosstalk and Injury
Project Summary Chronic kidney disease (CKD) is estimated to affect over 14% of US adults and is increasing in prevalence worldwide. The majority of cases are caused by glomerular diseases with sclerotic lesions, and transforming growth factor β expression in podocytes is a common stress response signal associated with segmental sclerosis. Using several experimental models of FSGS and DKD with proteinuria, we established a new hypothesis for “glomerular cell-cell crosstalk”, in which there is interdependence of the cells within the glomerular filtration barrier (GFB) for health and dysfunction. We showed that activation of podocytes results in TGFβ signaling followed by increased Edn1…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.