NIH R01 · 2025
Waves and noise in hippocampo-cortical circuit: a study of Alzheimer's disease
ABSTRACT Neurons in the brain are submerged into oscillating extracellular Local Field Potential (LFP) created by synchronized synaptic currents. The dynamics of these oscillations is one of the principal characteristics of the brain activity at all levels: from the individual neurons’ spiking to the activity of networks that underlie high-level cognitive processes. However, our interpretation of the LFP structure and functions depend on the techniques that we use for data analyses. The oscillatory nature of LFP motivates using Fourier methods, which have dominated LFP research for decades and currently constitute the only systematic framework for understanding the “brain rhythms.” Yet…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.