NIH R01 · 2025
Epigenetic and metabolic bottlenecks of tumorigenesis
Recurrent metastasis is the leading cause of breast cancer mortality. Dormancy is a critical, but poorly understood, step in the tumorigenic process where breast cancer cells can remain in a non-proliferative state at secondary sites for long periods of time after successful treatment of the primary tumor. Reactivation of dormant breast cancer cells (dDCCs) enables recurrent metastatic disease often resistant to standard of care therapies, and as such dDCCs represent a major clinical obstacle in breast cancer patient care. Chromatin remodeling provides the foundation for the cellular reprogramming necessary to drive cell fate transitions. However, little is known about the nature of this…
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