NIH R01 · 2024
New insights into extracellular signal transduction
PROJECT SUMMARY One of the most fundamental properties of cells is the ability to transduce signals to other cells and the surrounding environment. Well recognized modes of cellular signaling include direct cell-cell interactions via membrane receptors and ligands and the release of soluble factors, such as growth factors, cytokines and chemokines. The more recently described extracellular vesicle (EV) is now also considered as an important mediator of cell signaling, allowing cells to exchange proteins, lipids and genetic material. EVs are secreted from nearly all cell types and EV-based communication relies on the ability of vesicles to deliver bioactive molecules to other cells. The…
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