NIH R01 · 2024
Early diagnosis of light chain amyloidosis
PROJECT SUMMARY Light chain (AL) amyloidosis is a recalcitrant and deadly hematologic disease characterized by organ dysfunction from insoluble fibril deposition derived from clonal free light chains arising from a monoclonal gammopathy. The disease has a high early mortality of 40-45% at two years due to heart failure. Patients with advanced AL amyloidosis have high morbidity and mortality in the initial period after diagnosis owing to cardiac dysfunction. Despite experiencing multiple symptoms and demonstrating signs of the disease, many patients are diagnosed late, sometimes by years, because these ‘precursor diagnoses’ are often non-specific. Observational data also suggest that Black…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.