D'onofrio Lab

Trustees of Indiana University

PSYCHOLOGY

Bloomington · United States

NIH-funded
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NIH R01 · 2025

Examining the Effects of ADHD Medications on Substance-Related Morbidity and Mortality Among Young People

Youths and young adults with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for substance use disorders (SUD) and other SU-related morbidity and mortality. Clinical guidelines recommend pharmacotherapy as part of multimodal treatment, but the existing research estimating ADHD medication effects on SU problems is mixed and inconclusive. These inconsistencies are made more complex by several significant knowledge gaps that directly impair the clinical care of young people with ADHD. First, little is known about medication utilization and medication effects on SU problems among young people at high risk for such outcomes in the U.S., especially those enrolled in…

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