NIH R01 · 2024
The role of ferroptosis in red cell aging in vivo and in vitro
PROJECT SUMMARY Red blood cells (RBCs) are a perfect model to study oxidant stress. RBCs are the most abundant cell in the body (84% of total human cells) and play an essential role in oxygen transport and thus in the regulation of all oxygen-dependent metabolic processes. To facilitate this task, RBCs are loaded with hemoglobin (Hb) and iron. Indeed, 66% of total bodily iron is in RBCs. As a result, the mature RBC faces significant oxidant stress deriving from iron-dependent Fenton and Haber-Weiss redox chemistry. The lack of nuclei and organelles prevents RBCs from synthesizing new proteins to replace oxidatively damaged components during the average lifespan of 120 days in circulation.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.