NIH R01 · 2025
Metabolic effects of cooper in renal cancer
Clear cell renal cell carcinoma (ccRCC) is a frequent and malignant renal cancer with a glycolytic phenotype due to the loss of VHL tumor suppressor and activation of HIF transcription factors. Up to 50% of patients relapse within five years after surgical resection. Thus, there is an urgent clinical need to understand the molecular mechanisms leading to ccRCC relapse and advancement. Pathogenic mechanisms underlying ccRCC progression represent a key knowledge gap. Our recent discoveries demonstrate a copper accumulation in advanced ccRCC. In this proposal, we interrogate impact for copper-dependent metabolic reprogramming in driving ccRCC progression. Copper (Cu) is a metal cofactor of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.