NIH R01 · 2024
Administrative Supplement: Role of HELLS chromatin remodeler in genome maintenance
Project Summary Robust and tightly regulated DNA repair is critical to maintain genome stability and prevent disease development. Eukaryotic DNA is packaged into chromatin that has a profound, yet not well understood regulatory influence on DNA repair, replication and genome maintenance. There is a fundamental gap in understanding how DNA repair pathways are regulated and coordinated within structurally diverse chromatin, and across the heterogeneous genomic landscape. The HELLS (Helicase Lymphoid Specific) is a poorly understood chromatin-associated protein, with an emerging new role in genome maintenance. Mouse HELLS is essential for gametogenesis and proper development of the immune…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.