Cyster Lab

Research focus

NIH R01 · 2024

B lymphocyte Migration and Homeostasis

Dendritic cells (DCs) are critical antigen presenting cells for initiating adaptive immune responses. Their function depends on being positioned in sentinel locations at pathogen-exposed surfaces, and being present in tissues at appropriate densities. The major antigen-presenting DCs are called classical DCs (cDCs) types 1 and 2. cDC2s are particularly important for supporting T follicular helper (Tfh) cell and Th2 cell generation and are a focus of our efforts to broadly understand requirements for mounting antibody responses. In this application we will study requirements for cDC2 positioning, homeostasis and function in spleen and lung. Very recently, we found that splenic cDC2…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.