NIH R01 · 2025
Molecular and Computational Dissection of Cold Nociception
Project Summary / Abstract The long-term goal of this project is to elucidate the basic cellular, molecular, and physiological mechanisms of cold nociception. Thermosensory nociception is a specialized form of somatosensation, essential to the survival of all metazoans, that alerts the organism to potential environmental dangers coupled with pain sensation thereby serving as a protective mechanism for driving adaptive behavioral responses to safeguard against incipient damage. Despite this importance, the fundamental cellular, molecular, and physiological bases of cold nociception remain incompletely understood. Molecularly, transient receptor potential channels (i.e. thermoTRPs) play…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.