NIH R01 · 2025
Multiscale modeling of spatiotemporal evolution in Barrett's esophagus
PROJECT SUMMARY The practical goal of this project is to obtain high-resolution genetic and epigenetic maps that reveal the evolutionary relationships and dynamics over space and time in Barrett’s esophagus (BE). Barrett’s is the precursor to esophageal adenocarcinoma (EAC) therefore patients undergo surveillance exams to detect early cancers. Our study will provide an unprecedented level of molecular detail that has not been achieved in any previous study of pre-cancer evolution in BE. Importantly, the proposed experiments and analyses will define a BE patient’s “tissue phylogeography”, including significant features of clonal expansions that are predictive of BE progressing to future EAC.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.