Curatolo Lab

University of Washington

ANESTHESIOLOGY

Seattle · United States

NIH-funded
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NIH R01 · 2025

Identifying novel therapeutic targets for chronic neck pain: RNA-sequencing in human painful atlanto-axial arthropathy

PROJECT SUMMARY / ABSTRACT Background. Chronic neck pain is one of leading determinants of disability worldwide, a major contributor to the current opioid epidemic, and the cause of enormous health care expenditures. We currently do not understand which molecular mechanisms in the diseased tissues of the neck generate the painful signals that cause this disease burden. This gap in knowledge impedes development of effective, mechanism-specific therapeutics. Aim. We plan to use RNA sequencing on tissues taken from chronic neck pain patients undergoing surgery and then use computational biology and patient phenotyping techniques to gain better insight into molecular drivers that cause chronic…

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