NIH R01 · 2025
The Impact of Sex and Hippocampal Angiotensin II on Alzheimer's Disease
Abstract Alzheimer’s disease (AD) is the most common form of dementia in the aged population. An ongoing conundrum within the AD field is that despite women with dementia outnumbering men two to one, the efficacy of hormone replacement therapy appears to be limited. This suggests that the mechanism responsible for the increased risk of AD in women extends beyond direct hormone activity, wherein the neurobiological effects of sex hormones are dependent on other variables (e.g., angiotensin II). We and others have demonstrated that angiotensin II, a critical mediator of vasoconstriction, can amplify AD hallmarks in the brain, such as oxidative stress, amyloid plaques, and neurofibrillary tau…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.