NIH R01 · 2024
Processing and localization of the mechanotransduction channel subunit TMC1
PROJECT SUMMARY/ABSTRACT Hearing loss is the most common sensory deficit, often arising from dysfunction of cochlear hair cells. Hair cells express unique protein complexes vital for auditory function, including the mechanotransduction (MET) channel, a heteromeric protein complex which converts mechanical sound waves into electrical signals. Proper expression, assembly, trafficking, and localization of MET proteins to stereocilia are critical for auditory function, yet there is a significant knowledge gap in the molecules and mechanisms that participate in these processes. Numerous forms of hereditary hearing loss are associated with deficits in MET protein localization, making the study of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.