NIH R01 · 2025
Development of a novel NPY-sensitive microelectrode to detect endogenous NPY release
The main objective of this proposal is to develop an NPY-sensitive microelectrode for continuous measurement of NPY using an aptamer-modified platinum microelectrode with a total size of less than 25 µm. This will allow the research community to monitor endogenous NPY release in the intricate microenvironment of brain slices and single cells. In this way, we can establish connections between NPY levels and neurological disorders. To accomplish this, we propose a strategy for enhancing the detection of NPY by our previously developed NPY biosensor. Our initial findings indicate that our NPY-sensitive microelectrode can measure NPY with a sub-second time resolution, collecting 500 data points…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.