NIH R01 · 2025
Multidimensional and longitudinal immune profiling of sepsis in Uganda
PROJECT SUMMARY The global burden of sepsis is overwhelmingly concentrated in sub-Saharan Africa (SSA), where nearly 40% of all sepsis cases occur and up to 65% of all deaths are sepsis-related. While sepsis outcomes have improved over time in high-income countries (HICs), outcomes remain poor in SSA, with short-term mortality between 20- 50%. Further, sepsis treatment protocols developed in HICs have repeatedly shown harm when implemented in SSA. We argue that an imprecise understanding of sepsis pathobiology in SSA is a fundamental barrier to the development of effective treatment strategies. In contrast with HICs, sepsis in SSA occurs primarily in younger adults, inciting pathogens are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.