NIH R01 · 2025
Mechanisms of operant reward seeking in prefrontal somatostatin-expressing interneurons
Project summary Substance use disorder (SUD) is a debilitating disorder characterized by severe alterations in the neural circuits of reward. Among others, the gamma aminobutyric acid (GABA) system is a critical component of the pathology of SUDs. While historically studied in the context of alcohol use, the GABAergic system is now gaining more attention for its roles in mediating the rewarding properties of other drug types (such as opioids) and natural rewards. However, in comparison to other systems like dopamine, our understanding of the GABAergic mecha- nisms of reward seeking is far less complete. Like the fields of reward and addiction, a vast majority of studies of fear memory,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.