NIH R01 · 2025
Chronic intermittent Hx (CIH), a hallmark of obstructive sleep apnea and many other diseases, leads to a long- term increase in the strength of the peripheral chemoreflex (PCR). An enhanced PCR subsequently increases sympathetic nerve activity (SNA), leading to hypertension even in wakefulness, a major contributing factor to downstream cardiovascular diseases such as heart failure and heart failure, leading killers of Americans. Orexin neurons in the hypothalamus have high activity in wakefulness and project to corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVN), a nucleus known to facilitate the PCR via its projections to the nucleus of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.