NIH R01 · 2024
14-3-3-zeta regulation of islet health
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Pancreatic islet dysfunction is central to type 2 diabetes mellitus (T2DM) pathogenesis and consists of both α-cell and β-cell dysfunction. The regulation of α-cell and β-cell health is determined by a complex network of paracrine regulators that are incompletely defined. To improve the treatment and prevention of T2DM, it is critical to have a complete picture of α-cell and β-cell regulation. We have identified the signaling protein, 14-3-3ζ, as an important regulator of β-cell function and crosstalk between α-cells and β-cells. Specifically, recent work from…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.