NIH R01 · 2024
Control of MAPK Signaling by Cell Polarity Proteins
Signal transduction pathways function in interconnected networks comprising common or shared proteins. How specific signals are directed through a common protein module to induce a highly specific response is not clear. Some diseases like cancer can arise because a signal that is meant to follow one path is misdirected into another. One MAPK pathway in yeast regulates a microbial differentiation response called filamentous growth. In fungal pathogens, filamentous growth is required for virulence. The MAPK pathway is composed of G proteins and protein kinases that function in multiple pathways. A major regulator of the pathway is the Rho GTPase, Cdc42, which is widely considered a master…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.