NIH R01 · 2024
Tissue Engineered Rostral Migratory Stream for Directed Neuronal Replacement
PROJECT SUMMARY Chronic disability due to traumatic brain injury (TBI) affects 2% of the total population, and neuronal loss is generally considered permanent, owing to limited capacity for neuroregeneration in the adult mammalian brain. There are currently no approved treatments for improving recovery after TBI, and innovative approaches to enhance neuroregeneration are desperately needed. Intriguingly, new neurons are generated in the subventricular zone (SVZ) and then guided to the olfactory bulb/tract (and possibly striatum) via the rostral migratory stream (RMS) for integration into existing circuitry. Recent publications have demonstrated that SVZ neuroblasts can be redirected into…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.