NIH R01 · 2025
Investigation of Cognitive and Affective Deficits Post TBI Using Multimodal Flexible Neural Probes
PROJECT SUMMARY: Traumatic brain injury (TBI) is a global health crisis, and persistent cognitive-affective symptoms are common among TBI survivors. Methylphenidate (MPH), a dopamine (DA) transporter (DAT) inhibitor, has demonstrated improved outcomes with sex differences in the response. Our prior work suggests daily MPH treatment in rats with experimental TBI helps normalize electrically evoked striatal DA, but the effect on striatal basal DA level and the postsynaptic striatal medium spiny neurons (MSNs) has not been investigated. The other major striatal input, glutamatergic cortical neurons, can contribute to TBI-induced excitotoxicity. We hypothesize ongoing Glu-induced excitotoxicity…
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