NIH R01 · 2025
TCR signaling regulated T cell exhaustion in response to chronic viral infection
Summary Although it is becoming increasingly clear that CD8+ T cells responding to chronic infection are phenotypically and functionally diverse, little is known about how to overcome T cell exhaustion to treat infectious diseases. Using single cell RNA sequencing (scRNA-seq), the investigator’s team has confirmed the presence of previously identified TCF-1hi progenitor and PD-1hi exhausted T subsets. Surprisingly, they also found a CX3CR1+ effector subset at the late phase of chronic infection. More importantly, they have shown that CX3CR1+ effector cell formation is critically dependent on IL-21-producing CD4+ helper T cells. The discovery of this potent antiviral effector subset provides…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.