NIH R01 · 2025
Project Summary/Abstract: To understand the function and dynamics of neural circuits that control behaviors and cognitions, we need to observe the neuronal network at a cellular resolution over large spatial scales across multiple brain regions. Although two-photon fluorescence microscopy (TPM) combined with genetically encoded function indicators has provided a paradigm shift in neuroscience by enabling cellular resolution functional imaging deep in brain tissue, current TPM technologies still fall short of achieving whole-neocortex coverage. In this project, the engineering team at Purdue and the neuroscience team at UCSD will join the force to develop the Light Pipe Microscope (LPM) and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.