NIH R01 · 2025
Functions of mRNPs in RNA metabolism in Plasmodium falciparum
PROJECT SUMMARY The emergence of resistance to frontline therapies in the malaria parasite underscores the pressing need for sustained drug discovery and development efforts. Protein translation is largely unexplored in malaria parasites, yet recent studies highlight the translation machinery as a promising target for novel antimalarial drugs. Our work on the DDX6-family RNA helicase DOZI has uncovered that the human malaria parasite Plasmodium falciparum utilizes different membrane-less cytoplasmic messenger ribonucleoprotein (mRNP) granules to control protein translation. These granules, akin to processing bodies, stress granules, and germ cell granules in model eukaryotes, orchestrate…
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