NIH R01 · 2024
Developmental flame retardant exposure, gut microbiome, and obesity
PROJECT SUMMARY Obesity and type-II diabetes are a pandemic, causing grave social and economic burdens in the United States. Epidemiological and animal studies showed that the flame retardants polybrominated diphenyl ethers (PBDEs) and a most widely used current PBDE-alternative – tetrabromobisphenol A (TBBPA) are linked to obesity and diabetes. However, mechanisms governing early life exposure to flame retardants and obesity/diabetes remains unknown; no studies have compared the effect of PBDEs vs. TBBPA, and little is known regarding how early life flame retardant plus additional risk factors (e.g. dietary factors) later in life modulate obesity. The liver- and intestine-enriched pregnane…
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