NIH R01 · 2025
PROJECT SUMMARY/ABSTRACT: Action potentials are temporal changes of the electrical voltage across the cell membrane, which are crucial for the physiological function of excitable cells such as neurons and cardiomyocytes. In the human heart, cardiac action potentials coordinate the synchronous contraction and relaxation of billions of cardiomyocytes. The waveforms of intracellular action potentials reflect the coordination of a multitude of ion channels, some of which are affected by pharmaceutical drugs to collectively contribute toward proarrhythmic risks. The waveforms of intracellular action potentials also reflect the subtype such as atrial-, ventricular-, or nodal-like cardiomyocytes,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.