NIH R01 · 2024
Mitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ Dynamics
This MPI proposal has the overarching theme that mitochondrial Ca2+ uptake plays dual “ying-yang” roles when the heart is under stress: it ensures that extra energy demands are met under workload stress, while it is the route for Ca2+ overload/toxicity under oxidative stress. The project uses a new conditional knock- out rat model for EMRE/Smdt1, an essential subunit of the main mitochondrial Ca2+ uptake system, the mito- chondrial Ca2+ uniporter channel complex (MCUC). The excitation-bioenergetics (EB) coupling is a signaling loop that uses the Ca2+ released by sarcoplasmic reticulum (SR) to activate MCUC and generate mitochon- drial matrix Ca2+ signals to upregulate ATP production. Our…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.