NIH R01 · 2025
Regulation of RNA editing in two life cycle stages of Trypanosoma brucei
Pathogenic kinetoplastid protozoa, including Trypanosoma brucei, exhibit a remarkable mechanism of gene expression control by RNA editing. In most organisms, RNA is copied from DNA and directs protein synthesis without changes in the code. However, in trypanosome mitochondria (the ‘powerhouse’ of cells), mRNAs are remodeled by massive addition or removal of uridine residues. In their complex life cycle, trypanosomes alternate between two very different hosts: mammals (including humans) and insects, which are the vectors of transmission. The dramatically different environments that the parasites face in humans and insects demand rapid and large-scale metabolic and physiological changes,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.