NIH R01 · 2025
Contributions of the Adipose Tissue to the Development of Pancreatic Cancer
Project Summary Obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC), a cancer that has a dismal 5-year survival rate due to limitations in prevention and treatment. Obesity promotes PDAC tumorigenesis and worsens survival by increasing systemic inflammation, metabolic dysfunction, and chemotherapy resistance, but the mechanisms that drive tumorigenesis in obesity are unknown. Deleting lipocalin 2 (LCN2) in obese genetically engineered mouse models (GEMMs) of PDAC decreases inflammation in the tumor microenvironment and increases survival. LCN2 can bind lipid ligands like fatty acids (FAs), which are dysregulated in the plasma and adipose tissue of obese PDAC subjects.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.